A low neutrophil count along with a high lymphocyte count can be an indication of viral infections, autoimmune diseases and leukemias. MayoClinic.com explains that the spleen is normally an important infection-fighting and blood filtering organ, but if it becomes enlarged it may trap too many platelets 234. The following are important aspects about mean platelet volume. (7, 8), 35 Most Frequently Asked Questions About Coronavirus (COVID-19) – (with references). Platelet Distribution Width is a part of CBC (Complete Blood Count). Mean Platelet Volume (MPV) can also be useful in understanding the course of some clinical conditions such as stroke and ischemic bowel disease. wbc 3.9 rbc 4.27 hgb 12.8 low hct 38.5 low mpv 11.6 low lincho cites abs 1.1 low monocytes 10.0 high vit panel normal ave 56 diabético male Thor 2 for 24 vit b12 fólico normal what can i … A level of 7.5-11.5 femtoliters (one quadrillionth of a liter) is the normal range for mean platelet volume in most cases. Xu, J.W. List of 67 causes for Low blood platelet level and Low white blood cell count, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more. If you are experiencing serious medical symptoms, seek emergency treatment immediately. Nasreen Sultan & Santanu Kumar Sharma (2018). A low MPV is an indicator that the platelet in the blood is lower than normal, which puts you at risk for severe blood loss if you get injured. This can decrease white blood cell and platelet counts in the body. It could also indicate hyperthyroidism (over production of thyroid hormones). A high MPV means you have larger platelet size than normal while low MPV suggests a size that is smaller and older than normal. A teratogen is a substance that can cause birth defects. An elevated MPV is a good indicator to suggest the presence of larger and more reactive platelets which is likely a result of increased platelet turnover. There is a confirmed correlation between increased MPV and the risk of thrombosis. Ms. Gomez has a special focus on platelet-related illness prevention and health promotion. When the bone marrow is affected, production of both white blood cells and platelets can be hindered, leading to decreased levels in the body. Platelets are important components of the blood mainly involved in the blood clotting process. Xiucui Han, Pengfei Xu, Xiuzhi Duan, Yongxia Liu, Junfeng Zhang, & Hui Xu (2019). This could lead to increased platelet turnover, which will put you at risk for myocardial infarction. The test is specifically used to analyze the relationship between the production of platelets in the bone marrow and the destruction/consumption of the same. Photo source : images.wisegeek.com, Picture 2 : A microscopic presentation of platelets and red blood cells For example, a low or high platelet count will give a hint that the individual has developed abnormal levels which may be associated with an underlying blood disorder or medical condition. Aside from monitoring the volume of the platelet, other blood markers should also be checked, especially the white blood cells and red blood cells. Higher MPV can be due to excessive production of platelets from the bone marrow due to a condition called myeloproliferative disorders. Blood clumping is common in people with high mean platelet volume. Last reviewed by Dr. Raj MD on August 13th, 2018. If the disease targets bone, it can also damage the bone marrow and hinder the production of blood cells. Giving aspirin could further lead to bleeding. A high MPV and high platelet count indicates that the bone marrow is producing too much platelets. It is a condition that displays excessive production of thyroid hormones. There can be cases where the MPV is lower than average level. However, reading in between 9.7 fL and 12.8 fL is considered safe too. 1. Examples of common autoimmune diseases include allergies, rheumatoid arthritis and lupus. For instance, people in the Mediterranean region have shown to display a higher MPV than those in some other geographical regions. Autoimmune disorders occur when the body’s immune system attacks its own healthy tissue. Mean platelet volume (MPV) is part of the Complete Blood Count (CBC) test. When accompanied with normal platelet count, the low MPV suggests chronic kidney failure. This causes a decrease in the number of platelets in circulating blood, leading to serious bleeding disorders. If the platelet count is normal but the mean platelet volume is high, it could indicate chronic myeloid leukemia (over production of a specific type of white blood cells). Copyright © 2020 Leaf Group Ltd., all rights reserved. It is also checked in patients with several episodes of nose bleeding. Some cardiovascular risk factors such as smoking and hypertension can greatly influence MPV, based on the confounding factors like low-grade inflammation. These drugs are toxic to the cells and they should be used in moderation. If the level of platelet is high, it could indicate that you are suffering from acute myocardial infarction. By determining the level of MPV, the doctor can tell if the patient has high or low prognosis. Melissa Gomez, RN, MSN is a board certified nurse and has been a contributing writer for the past five years. It can also reflect the status of platelet production in the bone marrow. If the number of large platelets is high in a patient with a low platelet count, it is an indicator that the bone marrow is now producing sufficient level of platelets. The main objective in carrying out both tests is the detection and monitoring of specific disease activities in the blood, particularly relevant to the status of platelets. Cardiovascular factors can greatly affect the level of mean platelet volume. Individuals with an increased MPV are more likely to end up with blood disorders that may consequently result in death. Akshay Goel, Mayank Singhal, Abhishek Goel, L H Ghotekar, Hakan Paydak, & Jawahar L Mehta (2019). The normal range is between 7.2 fL and 11.8 fL in adults. Deonilson Schmoeller1, Maria Mercedes Picarelli, Terezinha Paz Munhoz, Carlos Eduardo Poli de Figueiredo, & imageHenrique Luiz Staub (2017). A normal MPV has a range of 7.5-11.5 femtoliters. Abnormal levels of these cells can be a sign of illness, disease or complications. The megakaryocytes are the precursors necessary in the production of platelets. It is significant in determining the functions of the bone marrow. Platelets and white blood cells are two of the main blood cell types in the body. In comparison to platelet count, mean platelet volume is used to help achieve a direct distinctive diagnosis between the different causes of thrombocytopenia, diseases of the bone marrow, and other bleeding disorders before it becomes evident with use of platelet counting. MPV Blood test is a part of the routine complete blood count (CBC). Her articles have been featured in "Women's Health," "Nutrition News," "Check Up" and "Alive Magazine."