Subscribe to Drugs.com newsletters for the latest medication news, alerts, new drug approvals and more. Terbinafine is an antifungal which selectively inhibits the early synthesis of ergosterol. In a target animal safety study, CLARO® was administered aurally to 12-week-old Beagle puppies (4 dogs/sex/group) at 0X, 1X, 3X, and 5X the recommended dose once every 2 weeks for a total dosing period of 28 days (3 times the treatment duration). Mometasone furoate is a glucocorticosteroid with anti-inflammatory activity. Use of topical otic corticosteroids has been associated with adrenocortical suppression and iatrogenic hyperadrenocorticism in dogs (see ANIMAL SAFETY). Keep this and all drugs out of reach of children. Use of topical otic corticosteroids has been associated with adrenocortical suppression and iatrogenic hyperadrenocorticism in dogs (see ANIMAL SAFETY). Clean and dry the external ear canal before administering the product. Available for Android and iOS devices. Description and Brand Names; Before Using; Proper Use; Precautions; Side Effects; Products and services. CLARO® should be administered by veterinary personnel. The integrity of the tympanic membrane should be confirmed before administering the product. CLARO ® Otic Solution is a fixed combination of three active substances: florfenicol (antibacterial), terbinafine (antifungal), and mometasone furoate (steroidal anti-inflammatory). Our general interest e-newsletter keeps you up to date on a wide variety of health topics. 9. In a field study conducted in the United States (see EFFECTIVENESS), there were no directly attributable adverse reactions in 146 dogs administered CLARO®. While holding the dropperette in an upright position, remove the cap from the dropperette. No consistent synergistic or antagonistic effect of the two antimicrobials was demonstrated. Do not use in dogs with known tympanic membrane perforation (see PRECAUTIONS). https://vetlabel.com/lib/vet/meds/claro-otic-solution/. Avoid contact with eyes. In case of accidental contact with eyes, rinse with abundant quantities of water and seek medical attention. Humans with known hypersensitivity to florfenicol, terbinafine hydrochloride, or mometasone furoate should not handle this product. Cleaning the ear after dosing may affect product effectiveness. Inactive ingredients include purified water, propylene carbonate, propylene glycol, ethyl alcohol, and polyethylene glycol. Copy the URL below and paste it into your RSS Reader application. this version. Treatment (1 mL) was administered once on Day 0 to the affected ear(s). CLARO® is indicated for the treatment of otitis externa in dogs associated with susceptible strains of yeast (Malassezia pachydermatis) and bacteria (Staphylococcus pseudintermedius). Do not use in dogs with known tympanic membrane perforation (see CAUTIONS). Florfenicol, Terbinafine hydrochloride, and Mometasone furoate Otic Solution. Good Alternative . Other potentially treatment-related effects included mild changes to aspartate aminotransferase, total protein, inorganic phosphorus, creatinine, and calcium. The adverse events listed here reflect reporting and not necessarily causality. RxNorm, Labels, All Index In case of accidental ingestion, contact a physician immediately.